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Organic Chemistry of Drug Degradation: RSC (RSC Drug Discovery) By Min Li
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- Sales Rank: #294784 in Books
- Brand: Brand: Royal Society of Chemistry
- Published on: 2012-09-25
- Original language: English
- Number of items: 1
- Dimensions: 9.21" h x 1.02" w x 6.14" l, 1.43 pounds
- Binding: Hardcover
- 306 pages
- Used Book in Good Condition
Review
"Due to the book’s broad scope and well-balanced coverage of obligatory and new aspects in drug stability research and quality assurance, it is of particular value to students and scientists in the field of pharmaceutical sciences."
"The book superbly introduces a broad readership into the arena of drug degradation and impurity testing." (Prof. Dr. Mario Thevis, German Sport University Cologne (Germany) ChemMedChem, DOI: 10.1002/cmdc.201300109)
"Overall, Organic Chemistry of Drug Degradation is an interesting read and provides the reader with concise information and up-to-date knowledge on chemical as well as analytical aspects of drug degradation." (Prof. Dr. Mario Thevis, German Sport University Cologne (Germany) ChemMedChem, DOI: 10.1002/cmdc.201300109)
"...the book provides the interested reader with a comprehensive, overview on all relevant aspects of drug degradation chemistries and analytical strategies." (Prof. Dr. Mario Thevis, German Sport University Cologne (Germany) ChemMedChem, DOI: 10.1002/cmdc.201300109)
From the Back Cover
A clear understanding of the organic chemistry of drug degradation is essential for maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events is the identification of drug degradants and the understanding of drug degradation mechanisms and pathways. This book is written by a veteran who has first-hand experience in drug design and development, degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which will aid greatly in efforts of degradant identification, formulation and analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation are discussed and illustrated with examples. The author brings the book to a close with two chapters on strategy for rapid elucidation of drug degradants and control of drug degradation with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is the one on Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex of all. This chapter employs more than sixty drug degradation case studies with in-depth discussion on their unique degradation pathways. With increasing regulatory requirements on quality and safety of pharmaceutical products, this book will be an invaluable resource for pharmaceutical and analytical scientists as well as medicinal chemists.
About the Author
Dr. Min Li is an Associate Director at Analytical Chemistry in Development and Supply - Supply Analytical Sciences Department of Merck & Co., Inc. He has led technical teams of senior-level scientists (Senior and Principal Scientists) for various analytical and pharmaceutical manufacturing process investigation and troubleshooting, impurity peak identification, study of drug degradation mechanisms, analytical method development, validation, specification setting, and support for new drug filing. He graduated from Fudan University and received his Ph.D. in Organic Chemistry from Johns Hopkins University, followed by a postdoctoral research at University of Illinois at Chicago in medicinal chemistry. Dr. Li was a Principal Scientist at Roche (1995 - 1998), a Scientific Fellow at Merck (1998 - 2005), and a manager at Schering-Plough (2005 - 2010). He was president of Sino-American Pharmaceutical Professionals Association (SAPA) between 2003 and 2004. Dr. Li is the first/primary author of more than 40 publications in a multi-disciplinary arena including organic, medicinal, bioconjugate, and analytical chemistry, as well as mass spectrometry. He has been invited to present in numerous international scientific meetings and conferences.
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